Are you Angela Gritti? Register this Author. Electronic address:. Raffaele, Milan, Italy. Toggle navigation. Sign In Join Now. Register this Author 51 Publications. Neurobiol Dis Feb 1; Epub Nov 1.
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Our work is focused on evaluating novel gene therapy strategies based on lentiviral-mediated gene transfer to the CNS , either as single treatment or coupled to neural and hematopoietic stem cell transplantation to target the PNS and periphery to treat neurodegenerative lysosomal storage disorders LSDs , rare genetic disease casues by genetic deficiency of specific lysosomal enzymes. A critical part of our research is devoted to clarify the early pathogenic events and the therapeutic mechanisms of disease correction upon treatments, in order to refine and implement the gene therapy strategies under testing. To address this issue we are exploiting several in vitro models, including patient-specific induced pluripotent stem cells iPSCs -based 2D and 3D cultures organoids. We are also expanding our disease portfolio and platforms, exploring CNS-directed gene editing strategies to address currently untreatable CNS disorders of glial cells. EMBO Mol. Stem Cells Transl. Cell Death Dis.
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These same principles have helped build strong, successful religious communities for thousands of years. You should both sit down and have a serious conversation about what you want and what she wants and if you can both deal with the compromise. As for me, I recall spending a lot of Sundays at sporting events with my dad.
Weirdly, one of the best sexes I ever had was with a lesbian who felt remorse and as though she had betrayed her fellow lesbians. She suggested instead watching something that was produced by the church itself. Right now she won't even watch a movie. I am so glad to have found this blog too. I'll keep being me and we'll see what happens. I am married to an OB physician 10 years. Nothing beats a face to face talk.